DNA polymerase theta-mediated DNA repair is a functional dependency and therapeutic vulnerability in DNMT3A deficient leukemia cells www.biorxiv.org/content/10.1101/2024.09.15.613155v1
Myeloid malignancies carrying somatic DNMT3A mutations (DNMT3Amut) are usually resistant to standard
ALU elements seem to require parts of LINE1 elements for transposition competence, even in stressed cells. One thing I find fascinating is that the duplication of p63 to form p73 and p53 occurred right around the time that DNA methyltrasferases started to specialize. p53 pulls down DNMT3A in co-IP.
Clonal hematopoiesis drives femoral atherosclerosis in middle-aged adults 🔬❤️📊 www.news-medical.net/news/2024090...#CardiovascularResearch#Atherosclerosis#ClonalHematopoiesis#GeneticMutations#DNMT3A#TET2#Heart#MiddleAge#PreventiveMedicine#Health
Researchers reveal that clonal hematopoiesis (CH) significantly increases the risk of developing femoral atherosclerosis, suggesting a unidirectional relationship independent of traditional cardiovasc...
In silico Exploration Natural Compounds for the Discovery of Novel DNMT3A Inhibitors as Potential Therapeutic Agents for Acute Myeloid Leukemia www.biorxiv.org/content/10.1101/2024.08.28.610083v1
Aberrant DNA methylation, a hallmark of acute myeloid leukemia (AML), is catalyzed by DNA methyltran
In silico Exploration Natural Compounds for the Discovery of Novel DNMT3A Inhibitors as Potential Therapeutic Agents for Acute Myeloid Leukemia www.biorxiv.org/content/10.1101/2024.08.28.610083v1
Aberrant DNA methylation, a hallmark of acute myeloid leukemia (AML), is catalyzed by DNA methyltran
Transcriptomic alterations including p53 pathway dysregulation prime DNMT3A mutant cells for transformation www.biorxiv.org/content/10.1101/2024.08.12.607467v1
DNMT3A mutations are prevalent in haematologic malignancies. Our mouse model introduced the murine h
Transcriptomic alterations including p53 pathway dysregulation prime DNMT3A mutant cells for transformation www.biorxiv.org/content/10.1101/2024.08.12.607467v1
DNMT3A mutations are prevalent in haematologic malignancies. Our mouse model introduced the murine h
Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss
'We studied two different leukemia driver mutations, Dnmt3a-R882H and Npm1cA, and found that the response to both mutations was highly variable across different stem cell states.' #Preprintwww.biorxiv.org/content/10.1...
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Mesenchymal Stromal Cell Senescence Induced by Dnmt3a-Mutant Hematopoietic Cells is a Targetable Mechanism Driving Clonal Hematopoiesis and Initiation of Hematologic Malignancy www.biorxiv.org/content/10.1101/2024.03.28.587254v1
Clonal hematopoiesis (CH) can predispose to blood cancers due to enhanced fitness of mutant hematopo