A most excellent molecule (and chemist) with which to conclude the week #SynChem#MedChem#DrugDesign#DrugDiscovery#MotW#chemskynew.enaminestore.com/catalog/EN30...

Re-post of my review of Leeson & Young (2015) Molecular Property Design: Does Everyone Get It? ACS Med Chem Lett 6:722–725 DOI: 10.1021/acsmedchemlett.5b00157 #MedChem#cheminformatics#DrugDesign#DrugDiscovery#chemskyfbdd-lit.blogspot.com/2016/02/the-...

The boys who cried wolf

So it's back to blogging and it's taken a bit longer to get into it this year since I had to finish a few things before leaving Brazil. ...

A most excellent molecule with which to conclude the week #SynChem#MedChem#DrugDesign#DrugDiscovery#chemskynew.enaminestore.com/catalog/EN30...

I’ve reviewed Landrum & Riniker (2024) Combining IC50 or Ki Values from Different Sources Is a Source of Significant Noise JCIM 64:1560–1567 DOI: 10.1021/acs.jcim.4c00049 #DrugDiscovery#DrugDesign#cheminformatics#DataScience#MedChem#chemskyfbdd-lit.blogspot.com/2024/09/vari...

Variability in biological activity measurements reported in the drug discovery literature

I'll open the post with a panorama from the summit of Shutlingsloe, sometimes referred to as Cheshire's Matterhorn, which at 506 m above sea...

A most excellent molecule with which to conclude the week #MotW#SynChem#MedChem#DrugDesign#DrugDiscovery#chemskynew.enaminestore.com/catalog/EN30...

A most excellent molecule with which to conclude the week #MotW#SynChem#MedChem#DrugDesign#DrugDiscovery#chemskynew.enaminestore.com/catalog/EN30...

A most excellent molecule (and chemist) with which to conclude the week #SynChem#MedChem#DrugDesign#DrugDiscovery#chemskynew.enaminestore.com/catalog/EN30...

A most excellent molecule with which to conclude the week #SynChem#MedChem#DrugDesign#DrugDiscovery#MotW#chemskynew.enaminestore.com/catalog/EN30...

Re-posting review of JMC Editorial (Property-Based #DrugDesign#DrugDiscovery#MedChem#PhysChem#cheminformatics#Ro5#LipE#LLE#Fsp3#logP#logD#metrics#chemskyfbdd-lit.blogspot.com/2024/07/a-no...

A Nobel for property-based drug design?

[This post was updated on 04-Aug-2024. I thank Tim Ritchie (see RM2009 | RM2014 ) for bringing  YG2003 (Prediction of Aqueous Solubility o...

A most excellent molecule with which to conclude the week #SynChem#MedChem#DrugDiscovery#DrugDesign#MotW#chemskynew.enaminestore.com/catalog/EN30...