Deletion of Il11 extended the lives of mice by 25% https://www.nature.com/articles/s41586-024-07701-9
Breakthrough in aging research: Blocking IL-11 extends lifespan and improves health in mice 🌟🔬🐭 www.news-medical.net/news/2024071...#Aging#Healthspan#LifespanExtension#IL11#MetabolicHealth#FrailtyReduction#CancerPrevention#Biomedical#Longevity@natureportfolio.bsky.social
Blocking IL-11 signaling extends lifespan and healthspan in mice, reducing age-related metabolic decline, frailty, and cancer incidence.
'As mice age, IL-11 is upregulated across cell types and tissues to regulate an ERK–AMPK–mTORC1 axis to modulate cellular, tissue- and organismal-level ageing pathologies. Deletion of Il11 or Il11ra1 protects against metabolic decline, multi-morbidity and frailty in old age.' #Immunology
IL-11 is identified as a key regulator of ERK–AMPK–mTORC1 signalling, metabolism, inflammation and age-related disease and lifespan in mouse and human.
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