A MicroED structure of the MAL TIR-mediated MyD88 TIR higher-order assembly reveals a two-stranded arrangement of TIR domains similar to MAL TIR self-assemblies #MicroED#MyD88#TIRDomaint.co/K0Jt3tVITD
Y. Li et al.: Microcrystal electron diffraction structure of Toll-like receptor 2 TIR-domain-nucleated MyD88 TIR-domain higher-order assembly #TIRDomain #MyD88 #IUCr https://journals.iucr.org/paper?S2059798324008210
This study addresses the structural basis of TIR-domain-mediated signal transduction in Toll-like receptor 2 pathways. It is demonstrated that TLR2, but not TLR1 or TLR6, TIR domains induce the formation of MyD88 TIR-domain assemblies in vitro. The MicroED structure of TLR2-induced MyD88 TIR assemblies determined at 2.85 Å resolution highlights conformational changes that are crucial for signaling and provides evidence that TLR2 can directly interact with MyD88 to initiate TLR signaling.