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3rd part of Dr. David Putrinoā€™s diagram: Hormonal. Drug Targets: šŸŸ¢ Testosterone šŸŸ¢ Bioidentical progesterone šŸŸ¢ Cortisol šŸŸ¢ Steroids #LongCovid#TreatLongCovid#UniteToFight2024

Network diagram headed Hormonal.
Drug Targets
- Testosterone
- Bioidentical progesterone
- Cortisol
- Steroids
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2/2. Further info. is on the website (ā¬‡ļø) including a list of the 15 UK sites so you can check if you are close by. Note: Inclusion criteria include having raised CRP since acute #COVID19#LongCovid#TreatLongCovidwww.phosp.org/phosp-i/

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LClongcovidsupport.bsky.social

2/3. Long Covid isn't mild, ability to do day to day activities is: āš ļø adversely affected for 1.5m āš ļø limited a lot for 381k These are predominantly working age people so this will affect the labour market. It's not 'sick note culture' Rishi - it's #LongCovid#TreatLongCovid

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šŸ“£ Paper out from the UKā€™s LOCOMOTION Study (including our Founding Member @nikki-s.bsky.social#LongCovid#TreatLongCovid#CureLongCovidwww.mdpi.com/1660-4601/21...

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NSnikki-s.bsky.social

šŸ§µ 3. I DO need: investigations to identify what is going on in my body and an effective treatment plan. šŸ”“ Link to posters ā¬‡ļø acrobat.adobe.com/id/urn:aaid:...#LongCovid#TreatLongCovid

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LClongcovidsupport.bsky.social

Long Covid Support Trustee Prof Danny Altmann talking at NHS National #LongCovid#TreatLongCovid#LongCovidRuinsLives

Slide with two columns headed ā€˜Proposed Mechanismā€™ and ā€˜Potential Therapeuticsā€™.
1. Axis of persistent virus - innate/adaptive immune activation - impaired tryptophan uptake: SARS-CoV-2 vaccines; antivirals, neutralising monoclonal antibodies (incl next-generation broad cross-reactivity
2. Reactivation of EBV (or other endogenous herpesviruses): EBV vaccine (as a therapeutic vaccine); ganciclovir
3. Immune subset changes, polarization, exhaustion, including mast cell activation: Steroids; antihistamines; anti-cytokine modulation; immune modulators; lessons from cancer immunotherapy
4. Autoimmunity: IVIG; plasmapheresis; steroids; immunosuppression; specific monoclonals
5. Dysbiosis: Faecal transplantation; probiotics; SCFA supplements such as butyrate
6. Hypercoagulation, microclots: Anticoagulation; apharesis
Man standing on a stage behind a lectern with microphone
Air quality monitor showing 21.4C 811 CO2ppm with a bar in the green section of a colour scale of green, yellow and red
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