New preprint from the lab describing how most poxviruses, including avipoxviruses, antagonise DNA-PK to block cGAS/STING-dependent interferon production during infection. www.biorxiv.org/content/10.1...
The sensing of viral nucleic acid by pattern recognition receptors (PRRs) is essential for initiation of a type-I interferon response against infection. Intracellular DNA sensing PRRs are responsible ...
'We find that DNA stimulus induced by chemotherapeutic agents leads to elevated expression of LAMTOR1 and promotes LAMTOR1 interacting with cGAS, facilitating the degradation of cGAS in lysosomes with the help of p62.' #Immunology#Immunotherapy#Immunoskywww.pnas.org/doi/10.1073/...
The study underscores the need to consider sex differences in Alzheimer's research and treatment. By identifying the role of immune pathways like cGAS-STING in the progression of Alzheimer's, particularly in individuals with high-risk genetic variants =>new strategies for treatment & prevention.
these aged microglia linger around and release inflammatory chemicals through a pathway known as cGAS-STING. Notably, the study found that these harmful effects were more pronounced in female mice, a finding that aligns with reports that APOE4 poses a stronger risk for women than men.
Selenium Attenuates Radiation Colitis by Regulating cGAS‐STING Signaling
Cgas deficiency promotes tumor growth by supporting B cell persistence and angiogenesis www.biorxiv.org/content/10.1101/2024.09.24.614699v1
The cGAS sensor activates STING/IFN signaling, which is crucial for immune defense against pathogens
Cgas deficiency promotes tumor growth by supporting B cell persistence and angiogenesis www.biorxiv.org/content/10.1101/2024.09.24.614699v1
The cGAS sensor activates STING/IFN signaling, which is crucial for immune defense against pathogens
The Senescence-Associated-Secretory Phenotype constituting HIF-1α activation is independent of micronuclei induction and associated cGAS-mediated interferon response www.biorxiv.org/content/10.1101/2024.09.25.615081v1
The Senescence-Associated Secretory Phenotype (SASP), characterized by the upregulation of inflammat
O Eloy toca pra caralho, tá maluco, monstro dms! www.facebook.com/share/v/cGAs...