Why? Well the female gut changes dramatically during pregnancy to increase nutrient absorption - perhaps that is why women seem to have more permeability over the life-course. We are doing some cool ongoing studies in vitro looking at male vs female monocytes ability to break the gut barrier. 10/n
Human studies are observational so we turned to mice to understand the chain of causality. Old female, but not male, mice did indeed have leakier guts and this seemed to be caused by TNF produced by the elevated number of circulating inflammatory monocytes. 8/n
Databases were downloaded. Which ones? A Necessary Role for Increased Biglycan Expression during L1-Mediated Colon Cancer Progression (??) SARS-CoV-2 Infected Cardiomyocytes Recruit Monocytes by Secreting CCL2 (in virto) 2/5
Using the “old way” for scRNAseq, we previously found a new transcriptional substate of monocytes enriched in sepsis. But we could only recruit at high-resourced academic medical centers. The ability to do scRNAseq with minimal work will enable this method to be applied anywhere with a -80 freezer.
Single-cell transcriptomic analysis identifies a distinct gene signature associated with peripheral monocyte populations that distinguishes people with sepsis from those with sterile inflammation and ...
My pleasure! Monocytes are a favourite. Always happy to share more!
academic.oup.com/discovimmuno... A good read about Monocytes!
Summary. Monocytes are a key component of the innate immune system. They undergo intricate developmental processes within the bone marrow, leading to diver
With the data we have, patient intrinsic T cell mechanisms are possible with an IFNg effect, and IFNRs are highly expressed, but less likely. DCs/monocytes seem hyper-activated, with high levels of IL6, but reduced stimulation capacity (CD28, MHC-II). 7/9
I spent several years persuading peripheral monocytes to become microglia. Great fun and a fine crossover between immunology and neuroscience. The innate immune cells are wonderful warriors. I love seeing them depicted in your work.
Expression of XCR1, CX3CR1, CSF1R and ADGRE1 on subsets of bovine blood dendritic cells and monocytes www.biorxiv.org/content/10.1101/2024.09.17.613502v1
Among dendritic cells (DC) and monocytes in blood of cattle we can distinguish conventional and plas
Expression of XCR1, CX3CR1, CSF1R and ADGRE1 on subsets of bovine blood dendritic cells and monocytes www.biorxiv.org/content/10.1101/2024.09.17.613502v1
Among dendritic cells (DC) and monocytes in blood of cattle we can distinguish conventional and plas