AH
Alex Holehouse
@alexholehouse.bsky.social
Asst. Prof. at WashU School of Medicine; biophysics/biochem/evolution of intrinsically disordered proteins. How does nature encode function without a stable structure? We work in vivo / in vitro / in silico. He/him.
532 followers536 following68 posts
This opens the door to the design of precise IDR-associated mutations that may fall outside of canonical binding motifs but will still enhance/suppress intermolecular interaction.
Also, check out the complementary preprint from @lindorfflarsen.bsky.socialwww.biorxiv.org/content/10.1...
Prediction of phase separation propensities of disordered proteins from sequence
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
AH
Alex Holehouse
@alexholehouse.bsky.social
Asst. Prof. at WashU School of Medicine; biophysics/biochem/evolution of intrinsically disordered proteins. How does nature encode function without a stable structure? We work in vivo / in vitro / in silico. He/him.
532 followers536 following68 posts