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Confidential and Pre-decisional Outcome of All ACTIV Agents Selected and Tested Through 2024 OX TESTED-UNSUCCESSFUL AT • Cenicriviroc • AZD7442 (IM)" (Outpatient) • AZD7442 (IV)" (Outpatient) INTERIM • Camostat Mesylate • BMS-986414/BMS- 986413 .LY-COV-555 (Inpatient) . . Brii-196/Brii-198 (Inpatient) VIR-7831 • DARPin MP0420 Pfizer PF-07304814" Aviptadil + Remdesivir (ARDS patients) • Remdesivir (ARDS patients)** Therapeutic Heparin + P2Y12 Inhibitors in Moderately-ill Pts • Crizanlizumab Aspirin Apixaban** • TRV027 • TXA127 • SGLT2 inhibitors • Fostamatinib TESTED-UNSUCCESSFUL AT FINAL TESTED- SUCCESSFUL • Infliximab OUTCOME ⚫Risankizumab . Lenzilumab Danicopan . Ivermectin (400) Ivermectin (600) . Fluticasone Fluvoxamine (50) • Fluvoxamine (100) . Prophylactic Heparin + P2Y12 Inhibitors in Critically-ill Pts Montelukast Shionogi-217622 (Did not meet primary endpoint in outpatient study in standard risk patients) Abatacept • Brii-196/Brii-198* (Outpatient) .LY-COV-555* (Outpatient)
EMORY EMORY EMORY EMORY Un-fractionated and Low Molecular Weight Heparin EMONY MORY FMORY B FMORY BANKY B EMORY . AZD7442 (IV)* (Inpatient) EMORY EMORY FMOKY FMA WY FAR WIT IMOWY MORY DMORY EMORY (MOWY BAW CAWY EMORY EMORY EMORY EMWY FAROWY BMWY EMORY EMOET FMORY IMCRY EMORY EMORY EMORY MANY BA BANY EMORY ill Timothy Buchman NOT YET DETERMINED NIH National Institutes of Health SNG001 IFN-beta (Phase 2)** SAB-185** Shionogi-217622 (Inpatient) Metformin *Received EUA or data from an ACTIV trial has or will contribute to an EUA filing **Ceased due to operational futility #Ceased due to company decision
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@alt-text.bsky.social
Email hsforeman98@gmail.com to report issues
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