My very first run and I already came into a dopamine-producing, broken-feeling combo: a Joker with insane multipliers for 3 card hands + a Joker that increases multiplier for ever Planet card + several Venus upgrades (elevating base 3-of-a-Kind scores). This does not bode well.

(I got beaten only when a "boss" specifically locked me out of playing hands smaller than 5 cards. It felt like the gaming recognizing how broken my combos were getting and surgically cut my shit out. It was fun to lose like that.)