Check out our new preprint where we assessed the assembly quality of IG loci in nearly finished vertebrate genomes, classified systematic errors and provided examples on how to fix these errors using curated and transparent genome assembly
Unveiling Assembly Errors in Immunoglobulin Loci: A Comprehensive Evaluation of Long-read Genome Assemblies Across Vertebrates https://www.biorxiv.org/content/10.1101/2024.07.19.604360v1
Long-read sequencing technologies have revolutionized genome assembly, addressing the limitations of
Check out our preprint describing a tool for reassembly of IG loci from LCLs containing somatic haplotypes produced by V(D)J recombination. We applied IgLoo to HPRC data and recovered many germline IG genes. We also revealed novel V(D)J recombination scenarios that might be confused with SVs
Happy to be part of this effort! We compared IG and TR loci across four apes and revealed rapidly evolving regions containing species-specific immune genes. This suggests an incredible variation of adaptive immune responses across closely related species. Check out the preprint for more stories!
Ruminant T2T paper is out! This is an open collaborative effort aiming to generate complete assemblies for agriculturally important and endangered ruminants and perform genomic analyses. Reach out to me if you are interested to join the immunogenomics working group! www.nature.com/articles/s41...
Here we describe an open collaborative effort termed the ‘Ruminant T2T Consortium’. It aims to generate complete diploid assemblies for many species of ruminants to examine chromosomal evolution in th...
Eric Engelbrecht in my lab showing us that we have much to discover in the human IGK locus! Gene conversions, novel inversions, SVs, SNVs, genes and alleles...oh my! rdcu.be/dJ8mL
Genes & Immunity - Resolving haplotype variation and complex genetic architecture in the human immunoglobulin kappa chain locus in individuals of diverse ancestry
Postdoc in my group, Oscar Rodriguez, will be discussing his work on genetic factors underlying variation in the developing BCR repertoire www.seqanswers.com/forum/site-n...
Registration is live for the upcoming AIRR-C VII Meeting! REGISTER NOW (whova.com/portal/regis...) AIRR-C Meetings VII - Learnings and Perspectives will be held in-person at the prestigious Faculty of Engineering, University of Porto, in Porto, Portugal from June 3-6/24.
Registration is live for the upcoming AIRR-C VII Meeting! REGISTER NOW (whova.com/portal/regis...) AIRR-C Meetings VII - Learnings and Perspectives will be held in-person at the prestigious Faculty of Engineering, University of Porto, in Porto, Portugal from June 3-6/24.
Digger, an automated tool for annotation of #immunoglobulin@williamlees.bsky.socialt.co/C6zwrHbUFz
Addressing technical pitfalls in pursuit of molecular factors that mediate immunoglobulin gene regulation biorxiv.org/cgi/content/...#biorxiv_genomic