BLUE
Login
EM
Elia Mascolo
@eliamascolo.bsky.social
PhD candidate at the Erill Lab. I love studying evolution through the lens of computational and theoretical biology. Math enthusiast and amateur jazz piano player.
53 followers99 following24 posts
EMeliamascolo.bsky.social

assembled correctly; (2) the LexA dimer contacts DNA with the known DNA binding domains in the DNA grooves; (3) it binds exactly on the "randomized" LexA sites (a pattern of 16 bp within the 40 bp). Here are the results on 8 sequences (we can't run >10 jobs/day at the moment) 5/

1
EMeliamascolo.bsky.social

In 8/8 cases, the TF complex is perfect, and targets DNA using correctly the DNA binding domains. In 4/8 cases, the binding occurs precisely on my "randomized" LexA sites. Uppercase: from PWM; lowercase: random; underlined red: binding expected; highlighted yellow: bound. 6/

AF3 places the LexA dimer on top of the random LexA sites in 4 out of 8 cases. The 8 sequences are shown and the positions where binding is observed are marked.
1
EM
Elia Mascolo
@eliamascolo.bsky.social
PhD candidate at the Erill Lab. I love studying evolution through the lens of computational and theoretical biology. Math enthusiast and amateur jazz piano player.
53 followers99 following24 posts
HomePopularExplore