🧬🧶#lorneproteins S6T4 Micha Rapé - how do protein aggregates kill cells? Ub init/elong/deUb. Diff chains encode diff information. Branched chains.. anti-aggregation. ubr5 1.2 MDa tetramer. Ubr4 1.3 MDa Complex SIFI. Mit protein import stress protective. Substrate traps.

HRI and DELE1. Dele1/HRI signals to shut down translation when mit import fails and aggregates are accumulating. SIFI complex only targets active DELE1/HRI for ubiuqitylation. Ubr ko active DELE1 stable.