Great opportunity to go work with Markus Arnoldini in the @mucosalimmunology.bsky.socialjobs.ethz.ch/job/view/JOP...
Metabolic exchanges are ubiquitous in natural microbial communities Nature Microbiology perspective by @kostchristian.bsky.social@sarilog.bsky.socialwww.nature.com/articles/s41...
Totally 🙃 thanks for commenting!
Interesting… so that would be acting in the opposite direction (with respect to succinate concentrations) to e.g. doi.org/10.1016/j.celrep.2021.109521
Hmmm… We show that both Phascolarctobacterium and Dialister consume succinate, but that (1) Dialister is slower and that (2) IBD patients are more likely to have Dialister compared to Phasco. How do you think that might influence mucosal healing?
Thanks, Karna!
In summary: Succinotypes stratify human gut microbiomes based on rate of succinate consumption, setting a mechanistic basis for a functional microbiome biomarker and therapeutic target. pharmabiome.comdoi.org/10.1101/2023...
Indeed, we looked at the association of succinotypes with different diseases and found that IBD patients are significantly more likely to have a D-succinotype compared to a P-type.
Finally, because succinate accumulation is implicated in disease—in particular IBD (e.g. doi.org/10.1007/s111... ) we hypothesized that this difference in consumption rate might provide a mechanistic link between microbiome function and disease pathophysiology.
Going back to the consumption rate differences, we expected D succinotype microbiomes to consume succinate more slowly than P succinotypes, and amazingly D-types had higher fecal succinate concentrations than P-types!
