Interesting… so that would be acting in the opposite direction (with respect to succinate concentrations) to e.g. doi.org/10.1016/j.celrep.2021.109521

Yes. It's a balancing act with combinatorical function where multiple cell type will sense multiple cytokines, each trying to tilt the system in an opposite direction. I guess that's why translating animal models to the clinic is so challenging.