Based on our deep mutational scanning, none of these mutations have an obvious strong effect on HA antigenicity or receptor usage (dms-vep.org/Flu_H5_Ameri...) (As always, caveat is that there could be some effect we are missing.)

Here are the locations of the mutations on the HA structure. Two are on the head, one is in the stalk. (Go to this link dms-viz.github.io/v0/?data=htt... to look at structure interactively)