I was intrigued and excited by new research using CAR T cells to tackle severe autoimmune disease. A few folks asked for an explainer so here is my attempt! Hope it’s useful 🧪 #ImmunoSky
Groundbreaking research out this week is taking a novel approach to help chronic disease
At no 4: ImmunoSky. Posts tagged with "⑂", #immunosky#lymphocyte@rodrahimi.bsky.socialbsky.app/profile/did:...
I’m curious about how strong TCR signals (low epitope load-high affinity/high epitope load-mid affinity) relate to T cell fate. Anyone have new publications (or opinions!!) to share on that topic? #Immunosky
NKR and IL-15 can lower the TCR activation threshold and endow CD8+ CTLs with the ability to kill targets that express IL-15 in a non-cognate yet TCR dependent manner: www.pnas.org/doi/10.1073/...
A major challenge of cancer immunotherapy is the persistence and outgrowth of subpopulations that lose expression of the target antigen. IL-15 is a...
www.nature.com/articles/s41...#immunosky IL-4 ♥️ but what’s it doing to TAMs?
Fc–IL-4, a typical type 2 cytokine, reinvigorates exhausted CD8+ T cells in tumours, underscoring this fusion protein as a potent immunotherapy that synergizes effectively with type 1 immunity against...
Afdeling genetica heeft absoluut mensen bij de kraam die een prima woordje Engels spreken!
I haven't seen a starter pack of immunologists, so I created one. Apologies if I overlooked folks. #ImmunoSkygo.bsky.app/PY5tCas
Oh boy, #ICDS24 in Sheffield is very much on! Incredible to see what has happened since last Celiac disease meeting. Much focus on Triggers, drivers, Viruses, B cells and more. It was an honor to give the scientific opening talk with the amazing @JonkersIris @ISSCD22 And this was only day 1…!
"Twitter did have some real value for science during COVID...Social media is a bit of a mess currently. Increasingly scattered people on increasingly scattered platforms. [I]f only there was a clear destination." Is Bsky the answer? kucharski.substack.com/p/why-twitte...
Reflecting on the positives among many negatives
