Check out our new preprint on PrgK, the cell-wall degrading enzyme of a Gram-positive Type 4 Secretion System that transports #antibiotic#virulence#AMR@rberntsson.bsky.socialwww.biorxiv.org/content/10.1...

PrgK has three extracellular domains. We here show that only one of the three domains is active, and in contrast to other known homologs in T4SSs it is actually a muramidase (MUR), instead of the proposed soluble lytic transglycosylase (SLT).