Plain language summary: we did cool shit with endometrial (uterine lining) cells showing the endo cells talk to proto-placenta cells but not vice versa. Even though people loooooove to tell science stories about placenta "invasion" as though it controls this whole process! The uterus is bossy!

BHprofharley.bsky.socialAug 30, 2024 4:55pm

#harleylab collaboration with @kateclancy.bsky.social 🧪🚨: Tissue engineering models of the decidualized endometrium to study crosstalk between endometrial microvascular complexity & trophoblast outgrowth. Great work by Dr. Zambuto, out now in npj women's health: www.nature.com/articles/s44...

Endometrial decidualization status modulates endometrial microvascular complexity and trophoblast outgrowth in gelatin methacryloyl hydrogels - npj Women's Health

npj Women's Health - Endometrial decidualization status modulates endometrial microvascular complexity and trophoblast outgrowth in gelatin methacryloyl hydrogels

Nice model! There’s some pretty good #Evolutionaryelifesciences.org/articles/74297

Gene expression phylogenies and ancestral transcriptome reconstruction resolves major transitions in the origins of pregnancy

Mammals evolved an invasive placenta early in the origins of pregnancy.

Congrats on the article, Kate. Sounds important.

Very neat! I wonder about how the unidirectional communication relates to the studies showing maternal selection of embryos. So to speak, embryos ought to communicate their status in one way or another. Or maybe it is only "low" quality embryos signalling their status?