You know SO MANY WOMEN w/ this story. Women miscarry all the time. Pregnancies fail all the time. We don't talk about any of it enough & most ppl have no idea how prevalent it is. But I guarantee you: You have women in your closest circles who miscarried & some of them brushed right up agst death.

🧪 Do you know how many immune cells you have? And where in the body they live? On average, the immune system consists of about 1.8 trillion cells, weighing around 1.2 kg! The most significant immunological organs are the bone marrow, lymph nodes, and spleen. 🔗study: shorturl.at/eiAf6

Plain language summary: we did cool shit with endometrial (uterine lining) cells showing the endo cells talk to proto-placenta cells but not vice versa. Even though people loooooove to tell science stories about placenta "invasion" as though it controls this whole process! The uterus is bossy!

BHprofharley.bsky.socialAug 30, 2024 4:55pm

#harleylab collaboration with @kateclancy.bsky.social 🧪🚨: Tissue engineering models of the decidualized endometrium to study crosstalk between endometrial microvascular complexity & trophoblast outgrowth. Great work by Dr. Zambuto, out now in npj women's health: www.nature.com/articles/s44...

Endometrial decidualization status modulates endometrial microvascular complexity and trophoblast outgrowth in gelatin methacryloyl hydrogels - npj Women's Health

npj Women's Health - Endometrial decidualization status modulates endometrial microvascular complexity and trophoblast outgrowth in gelatin methacryloyl hydrogels

new #harleylabonlinelibrary.wiley.com/doi/full/10.... Funding: NIDDK (NIH)

New #harleylabonlinelibrary.wiley.com/doi/10.1002/... Funding: NCI (NIH) & Cancer Center at Illinois

this work was heavily influenced by pioneering work from Helen Lu, who first thought about these concepts for differentiated cells (pubmed.ncbi.nlm.nih.gov/27599920/). We look at whether biomaterial-induced stem cell differentiation could drive similar interfacial growth for rotator cuff.

Cellular interactions regulate stem cell differentiation in tri-culture - PubMed

Currently, the mechanism governing the regeneration of the soft tissue-to-bone interface, such as the transition between the anterior cruciate ligament (ACL) and bone, is not known. Focusing on the AC...

#harleylabpubs.rsc.org/en/content/a... Funding NIAMS & NIDCR (NIH)

Paracrine signals influence patterns of fibrocartilage differentiation in a lyophilized gelatin hydrogel for applications in rotator cuff repair

Rotator cuff injuries present a clinical challenge for repair due to current limitations in functional regeneration of the native tendon-to-bone enthesis. A biomaterial that can regionally instruct un...

#harleylabonlinelibrary.wiley.com/doi/full/10....

Endometrial decidualization status modulates endometrial microvascular complexity and trophoblast outgrowth in gelatin methacryloyl hydrogels - npj Women's Health

npj Women's Health - Endometrial decidualization status modulates endometrial microvascular complexity and trophoblast outgrowth in gelatin methacryloyl hydrogels

#harleylab@kateclancy.bsky.socialwww.nature.com/articles/s44...

Endometrial decidualization status modulates endometrial microvascular complexity and trophoblast outgrowth in gelatin methacryloyl hydrogels - npj Women's Health

npj Women's Health - Endometrial decidualization status modulates endometrial microvascular complexity and trophoblast outgrowth in gelatin methacryloyl hydrogels

#harleylabonlinelibrary.wiley.com/doi/full/10.... Funding: NIDCR and NIAMS (NIH)

Donor Sex and Passage Conditions Influence MSC Osteogenic Response in Mineralized Collagen Scaffolds

Bone healing can vary as a function of sex, age, or pre-existing health conditions. Yet over 95% of tissue engineering and regenerative medicine studies using in vitro models fail to report donor sex....