#harleylabpubs.rsc.org/en/content/a... Funding NIAMS & NIDCR (NIH)
Rotator cuff injuries present a clinical challenge for repair due to current limitations in functional regeneration of the native tendon-to-bone enthesis. A biomaterial that can regionally instruct un...
this work was heavily influenced by pioneering work from Helen Lu, who first thought about these concepts for differentiated cells (pubmed.ncbi.nlm.nih.gov/27599920/). We look at whether biomaterial-induced stem cell differentiation could drive similar interfacial growth for rotator cuff.
Currently, the mechanism governing the regeneration of the soft tissue-to-bone interface, such as the transition between the anterior cruciate ligament (ACL) and bone, is not known. Focusing on the AC...