Our latest work is finally out! How #capsule#Klebsiella#phage#plasmid@epcrocha.bsky.socialdoi.org/10.1038/s414...
Bacterial capsules provide protection against the environment, including host immune systems. Authors swap capsule loci in Klebsiella pneumoniae to reveal the role of these sugar coats against plasmid...
I'm happy to chat to anyone who might be interested - get in touch, or come find me at the Wellcome AMR conference March 13-15.
JOB ALERT! Come work with me at LSHTM to investigate transmission of Klebsiella pneumoniae in neonatal units in Africa using bioinformatics and genomic epi. Great team, Gates funded, £44-50k/yr, 1-year postdoc to start with possibilities to extend. Closing March 26. jobs.lshtm.ac.uk/vacancy.aspx...
Check out our latest preprint! We explore the application of Nanopore Adaptive Sampling (NAS) for serotyping Streptococcus pneumoniae, and develop a new graph-based tool, GNASTy (pronounced ‘nasty’), to increase NAS sensitivity for detecting novel unobserved serotypes.
Graph-based Nanopore Adaptive Sampling with GNASTy enables sensitive pneumococcal serotyping in complex samples https://www.biorxiv.org/content/10.1101/2024.02.11.579857v1
Serotype surveillance of Streptococcus pneumoniae (the pneumococcus) is critical for understanding t
Friends, I wrote up a quick guide to getting started on Bluesky for folks who are used to old Science Twitter. Please share it with your folks who are joining. And please let me know if I missed anything or got anything wrong. 🧪 www.southernfriedscience.com/bluesky-is-n...
The once-great science twitter is, depending on who you talk to, either dying or dead. Once a vibrant place for many discussions related to my fields of marine biology, ocean conservation, and publ…
Phylogenetic tree statistics: a systematic overview using the new R package 'treestats' www.biorxiv.org/content/10.1...github.com/thijsjanzen/...cran.r-project.org/web/packages...
Collection of phylogenetic tree statistics, collected throughout the literature. All functions have been written to maximize computation speed. The package includes umbrella functions to calculate all...
Convergent within-host evolution alters key virulence factors in a Klebsiella pneumoniae clone during a large hospital outbreak www.biorxiv.org/content/10.1101/2024.02.06.577356v1
Bacterial pathogens adapt to host niches because of within-host selective pressures, and this evolut
New from the lab. We were stuck studying plasmid mobility because we ignored most origins of transfer by conjugation. Using the occurrences of known oriT, we developed a method to find novel unrelated families. Works well. We now cover most conjugative plasmids of E coli, K pneumo & A baumannii.
Identification of novel origins of transfer across bacterial plasmids https://www.biorxiv.org/content/10.1101/2024.01.30.577996v1
Conjugative plasmids are important drivers of bacterial evolution, but most plasmids lack genes for
Nearly 20 years ago, Jill Banfield, Gene Tyson & team transformed #microbiologywww.nature.com/articles/nat...
Follow for the latest news on the Genome Taxonomy Database (GTDB).