Loki was brought back, but it was completely worth it. He's also removed from the chess board by the end of the tv series. And Gamorra was put on a different trajectory after she was brought back due to timey wimey shenanigans. RDJ is being brought back as a completely different character.

The big character deaths of the Infinity Saga haven't been touched. Natasha, Tony and Steve are still dead/gone. T'Challa too (albeit bc of rl reasons). ...and I hope it stays that way fwiw. At least until Doomsday / Secret Wars where the entire point is kind of an "everyone is here" storyline.