The collaboration of a large team was essential for this interdisciplinary work: Mansooreh Ahmadian, Miriam D. Post, Rebecca J. Wolsky, Christian Rickert, Kimberly R. Jordan, Junxiao Hu, Jennifer K. Richer, Lindsay W. Brubaker, Nicole Marjon, Kian Behbakht, @mjsikora.bsky.social /11

The plaque recognizing Leigh Pate - our late advocate partner - and her gift to our group is finally up on the Benefactor Wall at CU Anschutz. I'm really excited that I can see this every day now, and am honored to have her name associated with our lobular research program.

Goddamn it, Ohio.

@jostrander.bsky.social@profriggins.bsky.social@zmadake2.bsky.socialacademic.oup.com/jes/advance-...

A path to precision metabolic treatment in breast cancer: riluzole, glutamate signaling, and invasiv...

Matthew J Sikora, Julie H Ostrander; A path to precision metabolic treatment in breast cancer: riluzole, glutamate signaling, and invasive lobular carcinoma, Jo

Hello chemistry and biology higher education bluesky world. Do you know of anyone who is interested in a career at a primarily undergraduate institution? I want to make you aware of the Consortium for Faculty Diversity www.gettysburg.edu/offices/prov...

We're charging ahead on this work, modeling the SNP in ovarian/gyn contexts in vitro and in vivo to learn more about how diff variant allele freq corresponds to diff gyn cancer biology and poor outcomes! Need to write the grants for the lobular half of the story now... 😅

5) The SNP is common, but variable - ranges from 0% in Black populations up to >50% in East Asian populations, and everywhere in between. 6) SNP may link gyn pathology risk (incr risk with variant allele) to outcomes disparities (diff tumor biology in our work)

4) WNT4 gene 'activation' is via converging mechanisms - in lobular, hijacked by estrogen receptor; in ovarian/gyn, a common SNP (at the lobular ER binding site) confers new regulatory context and activation.

1) Rather than typical Wnt secretion, we see WNT4 lives at mitochondria. Supports our prior data re: non-palmitoylated intracellular WNT4. 2) WNT4 controls shift from glucose metab --> more fatty acid/amino acid metabolism. 3) We see #2 in ILC+OvCa cell lines, and in Gyn tumors

Now online at Cancer Research Communications: "WNT4 regulates cellular metabolism via intracellular activity at the mitochondria in breast and gynecologic cancers" aacrjournals.org/cancerrescom... Quick highlights on implications in lobular breast cancer and ovarian cancer disparities -

MSmjsikora.bsky.socialDec 5, 2023 10:20pm

MANUSCRIPT ACCEPTED! This will be up soon at Cancer Research Communications, more to come! www.biorxiv.org/content/10.1...

WNT4 regulates cellular metabolism via intracellular activity at the mitochondria in breast and gyne...

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution