Now online at Cancer Research Communications: "WNT4 regulates cellular metabolism via intracellular activity at the mitochondria in breast and gynecologic cancers" aacrjournals.org/cancerrescom... Quick highlights on implications in lobular breast cancer and ovarian cancer disparities -

MSmjsikora.bsky.socialDec 5, 2023 10:20pm

MANUSCRIPT ACCEPTED! This will be up soon at Cancer Research Communications, more to come! www.biorxiv.org/content/10.1...

WNT4 regulates cellular metabolism via intracellular activity at the mitochondria in breast and gyne...

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

1) Rather than typical Wnt secretion, we see WNT4 lives at mitochondria. Supports our prior data re: non-palmitoylated intracellular WNT4. 2) WNT4 controls shift from glucose metab --> more fatty acid/amino acid metabolism. 3) We see #2 in ILC+OvCa cell lines, and in Gyn tumors

Big congrats all!