Für einen viel zu großen Teil der Politikjournalist*innen ist Demokratie inzwischen sowas wie Dschungelcamp: Promis wie Wagenknecht, die außer Talkshow-Bekanntheit nichts an politischem Gewicht besitzen, sind ihnen immer eine Sendung und eine Titelstory wert, und sie halten das für völlig okay.
Happy to share our latest publication, in which we developed a mass spec strategy to analyze the effects of chemical phosphatase activation on substrates and also indirect effects in cells: pubs.rsc.org/en/content/a...
Chemical activators and inhibitors are useful probes to identify substrates and downstream effects of enzymes; however, due to the complex signaling environment within cells, it is challenging to dist...
More details on the bribe-the-editors scandals that are becoming pervasive in some parts of scientific publishing. It's infuriating stuff, but I'd rather know that it's going on: www.science.org/content/blog...
Congrats!!!
There’s a frequent perception among recent entrants to drug discovery world that if we could just find drug candidates faster, this will be a useful accelerant to the overall process. The issue is: this thinking is mostly (but not entirely) incorrect. 🧵 1/
This paper showed up in my feed 15 years ago today, and still remains one of the most terrifying things I’ve ever read. May be a record-setter for the number of times the word “explode” appears in a JACS manuscript. cc: @safechem79.bsky.social
An impressive technique to generate macrocyclic peptide drug candidates - even more, ones that can actually be optimized to turn into drugs. www.science.org/content/blog...
A mea culpa: I should’ve posted on this review by Alex Zhavoronkov and coworkers a long time ago. It’s a steely-eyed, unflinching look at the (published) state of generative AI in preclinical drug discovery with the critical eye of a medicinal chemist.