Work in Nature Genetics by Samuel Taylor and Uli Steidl (Albert Einstein), showing how a small molecule inhibitor displaces the transcription factor PU.1 from one kind of motif to others in the genome, altering leukemia cell fate and inducing differentiation.

Pharmacological restriction of genomic binding sites redirects PU.1 pioneer transcription factor activity - Nature Genetics

Chemically driven blockade of PU.1 binding sites leads to its genome-wide redistribution. PU.1 network rewiring causes human acute myeloid leukemia cells to differentiate.