Enfin !!!! Edith Heard reçoit la médaille d’or 2024 du CNRS www.cnrs.fr/fr/presse/la...
Aujourd’hui directrice générale du Laboratoire européen de biologie moléculaire (EMBL) et professeure au Collège de France, Edith Heard est mondialement reconnue pour ses travaux pionniers sur l'inact...
Does one twirl on the Alps in a right-handed or left-handed helix? 😁
I'm delighted to release the first half of my new textbook in human genetics: web.stanford.edu/group/pritch... "An Owner's Guide to the Human Genome: an introduction to human population genetics, variation and disease"
Elegant work from Jyoti Nangalia, Peggy Goodell, Chiraag Kapadia (Wellcome Sanger, Baylor) detailing the frequency at which mutations occur in mouse hematopoietic stem and progenitor cells, and the kinetics of marrow clonal evolution during aging and under stress.
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
Work in Nature Genetics by Samuel Taylor and Uli Steidl (Albert Einstein), showing how a small molecule inhibitor displaces the transcription factor PU.1 from one kind of motif to others in the genome, altering leukemia cell fate and inducing differentiation.
Chemically driven blockade of PU.1 binding sites leads to its genome-wide redistribution. PU.1 network rewiring causes human acute myeloid leukemia cells to differentiate.
Wonderful work! Especially love the methylation profiling of flow-sorted chromosomes! Beautiful.
"Epigenetic control and inheritance of rDNA arrays" New preprint from the T2T acrocentrics team! We find a tight link between methylation and transcription of the rDNAs, including the occasional silencing of entire arrays www.biorxiv.org/content/10.1...
First author Niladri Sinha.
Fascinating work from Rachel Green, Sergi Redot, Alban Ordureau (Hopkins, MSKCC), reporting that the apoptosis induced by UV exposure is primarily due to RNA crosslinking and ribosome collisions, not DNA damage! Looking forward to delving into the details of this work. www.cell.com/cell/fulltex...
A comprehensive analysis of molecular and cellular changes following UV irradiation reveals that the ribotoxic stress response, rather than the DNA damage response, mediates UV-dependent programmed ce...