By employing #liver specific Alb-Cre, we found that body weights of the Alb-Orc2f/f mice were smaller than in the Orc2f/f animals of both sexes, though the liver size and liver size normalized to body weight was significantly smaller only in the females.

Histological examination of the livers unveiled that Orc2 deletion correlated with the presence of fewer, yet larger nuclei and cells. Our flow cytometry analysis further substantiated that Orc2 deletion promotes endo-reduplication in #hepatocytes.