Excited to share my latest with @kelleyharris.bsky.social@aaronquinlan.bsky.social, now out as an eLife "version of record!" We found evidence for a second germline mutator allele in a population of 🐁 RILs, adding even more complexity to the story of mutation spectrum variation in lab mice.

Epistasis between mutator alleles contributes to germline mutation spectrum variability in laboratory mice

Germline mutation rates in mice are shaped by two mutator alleles that interact epistatically, showing that DNA repair defects that map to different loci can have snowballing effects.