Finally this draft is out! The question is: how often do we find the same plasmid in different bacterial hosts in the same patient? Spoiler alert: in this dataset very often!

BBbiorxiv-bioinfo.bsky.socialSep 30, 2024 3:47am

Plasmid conjugation drives within-patient plasmid diversity https://www.biorxiv.org/content/10.1101/2024.09.27.615342v1

Plasmid conjugation drives within-patient plasmid diversity https://www.biorxiv.org/content/10.1101/2024.09.27.615342v1

Plasmids are well known vehicles of antimicrobial resistance (AMR) genes dissemination. Through conj

First off: why do we care? In a plasmid outbreak, thanks to plasmid conjugation, we can find the same plasmid in different bacterial hosts and this could muddle our uncovering of the outbreak. Understanding how often this happens can help us devise appropriate screening.