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CP
Chris Ponting
@cgatist.bsky.social
Disease genomics & molecular mechanisms; ME/cfs: decodeme.org.uk/portal/ @ Edinburgh University. Views - my own. He/him.
270 followers44 following6 posts
CPcgatist.bsky.social

Lovely to chat to Jennie Jacques about #MEcfs#DecodeMEt.co/bijeB3WQ2e

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Reposted by Chris Ponting
JPjkpritch.bsky.social

Two new chapters from my free online book in human genetics out this weekend! These complete Part 3 of the book, on human population structure and history: 3.3: Human prehistory [separate thread] 3.4: Ancient DNA: a genetic time capsule [this thread] web.stanford.edu/group/pritch...

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Reposted by Chris Ponting
TKtomkindlon.bsky.social

Call for US RECOVER Initiative to include ME/CFS www.meresearch.org.uk/call-for-us-...#MECFS#LongCovid

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Reposted by Chris Ponting
NHnaomidharvey.bsky.social

🚨‼️Biggest ever blood based study of people with ME versus controls shows a clear signature of disease *not connected to activity levels* that relates largely to chronic inflammation, insulin resistance and the liver disease‼️ 🚨 By @cgatist.bsky.socialwww.medrxiv.org/content/10.1...

Replicated blood-based biomarkers for Myalgic Encephalomyelitis not explicable by inactivity
Replicated blood-based biomarkers for Myalgic Encephalomyelitis not explicable by inactivity

medRxiv - The Preprint Server for Health Sciences

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CPcgatist.bsky.social

No more does a cell need to be placed at a single location in expression space. Stator allows cells to be labelled with many biological states. Work with dream team: Abel Jansma, Yuelin Yao, Jareth Wolfe, Luigi Del Debbio, Sjoerd Beentjes & Ava Khamseh Please send feedback!

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CPcgatist.bsky.social

Stator finds: 👉Sub-phases of the cell cycle, 👉Future fate of mouse embryonic cells, 👉Rare cell sub-types & 👉Cycling transformed cells whose expression signatures are prognostic in cancer. Example: Medium spiny neurons (MSN) from Direct pathway, with intermediate maturity

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CPcgatist.bsky.social

Stator works by finding high-order gene expression dependencies in sparse #scRNA seq data. The method is data driven & comes with its own Shiny App. Finds up to n=7 gene dependencies of expression OR non-expression.

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CPcgatist.bsky.social

NEW PAPER Know that clustering single cells in reduced dimensions is problematic? Want to identify cell subtypes or states *without* clustering? Then check out Stator which finely resolves states & subtypes even among apparently homogeneous cells 🧵 www.biorxiv.org/content/10.1...

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Reposted by Chris Ponting
TKtomkindlon.bsky.social

In May 2023, the ME Association requested the latest mortality data from the Office for National Statistics (ONS) & discovered that between 2001 and 2021,150 deaths in England & Wales were partly or fully attributable to ME/ #CFSmeassociation.org.uk/2023/11/me-a...#MEcfs

ME Association Research Review: Mortality in ME/CFS - The ME Association
ME Association Research Review: Mortality in ME/CFS - The ME Association

Malnutrition is the most serious life-threatening complication in those with ME/CFS, especially in very severe cases.

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CP
Chris Ponting
@cgatist.bsky.social
Disease genomics & molecular mechanisms; ME/cfs: decodeme.org.uk/portal/ @ Edinburgh University. Views - my own. He/him.
270 followers44 following6 posts