EM
Elia Mascolo
@eliamascolo.bsky.social
PhD candidate at the Erill Lab. I love studying evolution through the lens of computational and theoretical biology. Math enthusiast and amateur jazz piano player.
53 followers99 following24 posts
at which the site starts is also random (Uniform) so that the sequence may not be in the center. I input the sequence of LexA, and set "Copies" to 2 because LexA acts as a dimer. I then try AF3 on the sequences I generated. I consider the test passed if: (1) the dimer is 4/
assembled correctly; (2) the LexA dimer contacts DNA with the known DNA binding domains in the DNA grooves; (3) it binds exactly on the "randomized" LexA sites (a pattern of 16 bp within the 40 bp). Here are the results on 8 sequences (we can't run >10 jobs/day at the moment) 5/
EM
Elia Mascolo
@eliamascolo.bsky.social
PhD candidate at the Erill Lab. I love studying evolution through the lens of computational and theoretical biology. Math enthusiast and amateur jazz piano player.
53 followers99 following24 posts