🧬🧶 Pre-print out now: 🌲 S-lignin O-demethylation by a heme peroxygenase. If you're lucky enough to have a student like Alix Harlington, you'll know the warm glow you get from supporting work of this calibre. Check out our current favourite #P450tinyurl.com/nfe36afb
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
🧬🧶 #lorneproteins ⚡️ Gabby Watson - Nbs to help cross the BBB. E.g. Transferrin receptor - repurpose? Brain shuttle. Fab+Ab that targets Tfr1. 940 Nbs screened 🦸♀️. Binding affinity- high affinity isn't good. Likely to get routed to lysosomes. Mod affinity. Fluo label - 🧠✅️🫶👏
🧬🧶 #lorneproteins ⚡️ Joanna New: Tauopathies - symptoms of CTE overlap with other Tauopathies. Only evident in death. Characterising novel amyloid binding probes. Recombinant Tau fibrils - observe probe+/- amyloid. 👏🫶
🧬🧶 #lorneproteins ⚡️ @acmarshallphd liquid protein demixing for subcellular organisation. DBHS proteins RNA/DNA binding proteins. In paraspeckles. Prion-like N-LCR not main driver of demixing... attenuated. C-LCR higher pass separation. 🫶👏 Great talk Andrew. 🎷👌🤣
#lorneproteins ⚡️ talks: Vanessa Morris-Caspase8 master reg apoptosis. Dimerisation, autocat cleavage to active dimer. HOSCN impact on cell death pathways? Necroptosis...unpublished? Maybe. 🤐🤩👏
🧬🧶#lorneproteins S6T4 Micha Rapé - how do protein aggregates kill cells? Ub init/elong/deUb. Diff chains encode diff information. Branched chains.. anti-aggregation. ubr5 1.2 MDa tetramer. Ubr4 1.3 MDa Complex SIFI. Mit protein import stress protective. Substrate traps.
🧬🧶 #lorneproteins S6T2 Catherine Day-Traf6 key RING E3:inflammation. Dimer requiring ZFs; maintain closed state. Stable heterodimers; trimers that are more active-bind K63 Ub chains. RNF125-RING/ZF/UIM-Ub dependent proteasomal degradation_Activity enhanced by Ub backside binding.👏
🧬🧶 #lorneproteins Anders ECR awards: S5T3 Chris Horne. All unpublished. CaMK family, cellular influx of Ca.. sensing and signaling dependent on Ca. Calmodulin cinf change + Ca, effector binding. Hydrophobic ⚓️, EF-hand motif... to Dark Kinases... 🤫😎 🫶👏
🧬🧶#lorneproteins Anders ECR awards S5T2: Xin Zhang - GPCRs full, partial, neutral or inverse agonism. Semaglutide binds EC domain and Nterm inside TMD. Synthetic agonists... ECL3/TM7 diff conf w different ligand binding sites. MD simulations ❤️ Struc insights into biased agonism. 🫶👏
