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Luke Pilling
@lcpilling.bsky.social
PhD. Genetic epidemiologist researching disease mechanisms @ University of Exeter, UK ❤Rstats. UCU rep✊. Views my own. He/him. 🏳️‍🌈ally. 🇬🇧🇪🇺. 📷 ShowYourStripes.info W: ex.ac.uk/lcpilling
135 followers153 following31 posts
LPlcpilling.bsky.social

I think the problem was I was trying with the new "fine-grained tokens" rather than the classic "personal access tokens" -- the below works fine for private repos! system("git clone [https://]<personal_access_token>@github.com/repo.git") Many thanks to Lauric Ferrat for pointing this out to me

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LPlcpilling.bsky.social

Great idea. Honour to be included! Thank you. BSky really taking off now

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LPlcpilling.bsky.social

It takes <30 seconds on my Linux server to go from a list of diagnostic codes to "date first diagnosed, any source" phenotype. It takes longer on Windows due to slower grepping of text files (~4 minutes). On the RAP it takes ~5 minutes to get the data from spark

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LPlcpilling.bsky.social

Lots of caveats regarding the use of polygenic scores in non-EUR groups, but we aimed to apply the principles outlined in the recent report to the best of our current abilities, but future studies should move away from discrete ancestry clusters doi.org/10.17226/26902

Using Population Descriptors in Genetics and Genomics Research: A New Framework for an Evolving Fiel...
Using Population Descriptors in Genetics and Genomics Research: A New Framework for an Evolving Fiel...

Read online, download a free PDF, or order a copy in print or as an eBook.

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LPlcpilling.bsky.social

Yes. Twitter had it's failings but I saw more relevant papers outside my direct followers then here, I presume due to "the algorithm" pairing me to similar posts/topics etc.

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LPlcpilling.bsky.social

There seems to be a paper for every combination these days. I'm not saying all are bad - there are some good ones, and I review the ones in my area when I have the time - but many seem very superficial "We get these public summary stats for these two traits, got the IVW estimate, and here's a paper"

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LPlcpilling.bsky.social

Time to invite some stats people!

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LPlcpilling.bsky.social

😉🧐

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LPlcpilling.bsky.social

Once in a JupyterLab environment on a Spark Cluster the following R commands pull the data straight from the database without intermediate files Takes ~5 minutes to build all the package dependencies, and <5 minutes to get the data object

R syntax to use ukbrapR::get_rap_phenos
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LP
Luke Pilling
@lcpilling.bsky.social
PhD. Genetic epidemiologist researching disease mechanisms @ University of Exeter, UK ❤Rstats. UCU rep✊. Views my own. He/him. 🏳️‍🌈ally. 🇬🇧🇪🇺. 📷 ShowYourStripes.info W: ex.ac.uk/lcpilling
135 followers153 following31 posts