Through the breeding of Orc2f/f mice with Sox2-Cre mice, our study demonstrated the essential role of ORC2 in #embryonic#development. Notably, the proliferation rate of Orc2f/f mouse embryonic fibroblasts (MEF) infected with adeno-Cre was significantly impaired.

By employing #liver specific Alb-Cre, we found that body weights of the Alb-Orc2f/f mice were smaller than in the Orc2f/f animals of both sexes, though the liver size and liver size normalized to body weight was significantly smaller only in the females.