The double knockout (dKO) of Orc1 and Orc2 led to another round of intriguing findings. H&E staining showed that dKO female livers exhibited significantly fewer but larger cells with notably larger nuclei compared to male livers. #SexSpecificDifferences

dKO female mice showed a significant decrease in size. We have also observed ~50% lethality of dKO female mice within the first month of life, but the remaining 50% survive beyond 4 months of age. #Female#morbidity#mortality than male mice.