Had so much fun in the Chewbacchus parade this weekend!!! Brainiac Krewe y’all are the best!!!! Happy Mardi Gras everybody!!!!! @caitismuheil.bsky.social@agunderson.bsky.social@tropicalbotany.bsky.social
Such a great visit! Lots of fun science, people, and of course always lovely to spend some time with Mimulus. Thanks @ferrisifolius.bsky.social, you're the best!!
Mutations in yeast are deleterious on average regardless of the degree of adaptation to the testing environment www.biorxiv.org/content/10.1101/2024.01.09.574908v1
The role of spontaneous mutations in evolution depends on the distribution of their effects on fitne
We speculate that the decreased crossover and shuffling helps facilitate the purging of introgression in the early generations following hybridization. Eager to hear others thoughts!
We employ the tool r bar (pubmed.ncbi.nlm.nih.gov/30635424/) to measure the amount of allele shuffling, and find that the decrease in crossovers in introgression translates to decreased shuffling on many chromosomes with introgression.
We find that heterozygous introgression significantly changes the recombination landscape. Crossovers are decreased and non-crossovers are increased in regions of heterozygous introgression (similar to what is seen in heterozygous inversions!)
Recombination plays an important role in the distribution of introgression in the generations following hybridization in lots of species 🦋🌽🐟👩🔬 We use the awesome power of yeast to WGS the meiotic products of two crosses, one with introgression and one without, and call crossovers and non-crossovers
I'm excited to share our new preprint, "The recombination landscape of introgression in yeast," lead by Enrique Schwarzkopf w/ Nathan Brandt. This paper combines two of my favorite things - recombination and hybridization! Some findings here 🧵 www.biorxiv.org/content/10.1...
These are awesome! Heil lab Postdoc Enrique Schwarzkopf received one of these to use sourdough to teach middle schoolers in Durham NC about evolution!
One step closer to a draught genome
Another very important paper published today The origins of the Guinness stout yeast www.nature.com/articles/s42... 🧬🖥️
A genomic analysis of 22 S. cereviseae yeast strains used in beer brewing suggest that yeast used to brew Guinness form a distinct evolutionary sub-clade, and that the modern-day Guinness yeast is c...